Journal: Brain Sciences
Article Title: Brain Markers of Resilience to Psychosis in High-Risk Individuals: A Systematic Review and Label-Based Meta-Analysis of Multimodal MRI Studies
doi: 10.3390/brainsci15030314
Figure Lengend Snippet: Diffusion-MRI studies.
Article Snippet: Kim et al., 2012 [ ] , 22 FHR (FDR $ , 23 yr, 36% M) 15 SCZ (23 yr, 53% M) 26 HC (22 yr, 50% M) , 1.5T Siemens Avanto: DWI scan (TR 5.9 s, TE 96 ms, FOV 23 cm, axial slices of 2 mm, no gap, voxels 1.8 mm 2 × 4 mm, b-value 1000 s/mm 2 , and 12 non-collinear directions) , FSL preprocessing. Callosal boundaries traced with Moore–Neighbor algorithm, CC segmented into 200 equidistance surface points, and FA extracted from each. , FA of each surface point assessed for group effects with ANOVA, using age and sex as covariates and using random permutation with p < 0.01 to control the type 1 error rate. , While SCZ showed the decreased FA of CC splenium and genu (trend), FHR had an increased FA of the genu , which may reflect compensatory WM changes counteracting the influence of the genetic vulnerability to psychosis..
Techniques: Diffusion-based Assay, Software, Transformation Assay, Control, Sequencing, Comparison